Aescin – a natural soap for the formation of lipid nanodiscs with tunable size. Ramsia Geisler, Martin Cramer Pedersen, Natalie Preisig, Yvonne Hannappel, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg.International Journal of Molecular Sciences 2021, 22 Is the Membrane Lipid Matrix a Key Target for Action of Pharmacologically Active Plant Saponins?. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia) 2021, 18 Treatment of hemorrhoids in a comorbid patient: selection of a preparation of plant origin. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM.
Carina Dargel, Friederike Gräbitz-Bräuer, Ramsia Geisler, Pascal Fandrich, Yvonne Hannappel, Lionel Porcar, Thomas Hellweg.Journal of Surfactants and Detergents 2021, 13 Effect of the oat, horse chestnut, cowherb, soy, quinoa and soapwort extracts on skin‐mimicking monolayers and cell lines. Ilona Jurek, Aleksandra Szuplewska, Michał Chudy, Kamil Wojciechowski.Moulding hydrodynamic 2D-crystals upon parametric Faraday waves in shear-functionalized water surfaces. Mikheil Kharbedia, Niccolò Caselli, Diego Herráez-Aguilar, Horacio López-Menéndez, Eduardo Enciso, José A.Interaction of the Saponin Aescin with Ibuprofen in DMPC Model Membranes. Ramsia Sreij, Sylvain Prévost, Carina Dargel, Rajeev Dattani, Yvonne Hertle, Oliver Wrede, Thomas Hellweg.Aescin-Induced Conversion of Gel-Phase Lipid Membranes into Bicelle-like Lipid Nanoparticles. Ramsia Geisler, Martin Cramer Pedersen, Yvonne Hannappel, Ralf Schweins, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg.
This article is cited by 18 publications. Furthermore, a destructuring role was revealed for aescin on phospholipid membranes, similar to the fluidizing effect of cholesterol and nonsteroidal anti-inflammatory drugs (NSAIDs) on lipid bilayers. From LT studies in monolayers, the interaction of aescin with DMPC was shown to be stronger in the condensed phase than in the liquid expanded phase. Above this concentration, aescin–aescin interactions dominate, which inhibit vesicle formation but lead to the formation of new membrane aggregates of smaller sizes. Below 7 mol %, the results reveal phase segregation of nanometer-sized aescin-rich domains in an aescin-poor continuous bilayer.
The binary interaction was found to strongly depend on aescin concentration in two well differentiated concentration regimes. The binary membranes are experimentally studied on different length scales ranging from the lipid headgroup area to the macroscopic scale using small-angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and differential scanning calorimetry (DSC) with binary bilayer vesicles and Langmuir tensiometry (LT) with lipid monolayers spread on the surface of aescin solutions. Using model membranes in the form of lipid vesicles and Langmuir monolayers, we study the mixing properties of aescin with the phase-segregating phospholipid 1,2-dimyristoyl- sn-glycero-phosphocholine (DMPC). The saponin aescin from the horse chestnut tree is a natural surfactant well-known to self-assemble as oriented-aggregates at fluid interfaces.